Genomic Signatures of Exceptional Longevity and Negligible Aging in the Long-Lived Red Sea Urchin

Abstract

The genome of the long-lived red sea urchin was analyzed and compared with short-lived species, revealing chromosome rearrangements and expanded gene families linked to immunity, nervous system, and genome stability. Genes under positive selection related to genomic regulation, protein homeostasis, and mitochondrial function suggest mechanisms for maintaining tissue homeostasis, disease resistance, and negligible aging.