Early-life stress triggers long-lasting organismal resilience and longevity via tetraspanin
Authors:Wei I. Jiang,Henry De Belly,Bingying Wang,Andrew Wong,Minseo Kim,Fiona Oh,Jason DeGeorge,Xinya Huang,Shouhong Guang,Orion D. Weiner,Dengke K. Ma
DPID: 145Published:
Abstract
Early-life thermal stress in C. elegans leads to lasting up-regulation of the tsp-1 gene, crucial for membrane functions and resilience. This effect, requiring the CBP-1 enzyme, results in enhanced longevity and thermal resilience, demonstrating how early stress has long-term impacts.